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In the BTBR mice, positive allosteric modulation of the α7 nicotinic acetylcholine (nACh) receptor with AVL-3288 at higher doses (3–10 mg/kg), or the compound 4–327, proved to be effective in alleviating both deficits in social interactions and repetitive self-grooming behaviors [56]

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However, an assay that measures glutamate release can be used to measure the hydrolysis of physiologic substrates by GGT5